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ProteomicsProteomic interactome of C. elegans Mediator complex subunit 28 (MDT-28) reveals predominant association with a restricted set of core Mediator subunits and an affinity to additional structural and enzymatic proteins
Transcription factors exert their regulatory potential on RNA Polymerase II machinery through a multiprotein complex called Mediator complex or Mediator. The Mediator complex integrates regulatory signals from cell regulatory cascades with the regulation by transcription factors. The Mediator comple...
ORGANISM(S): Caenorhabditis elegans 
2020-07-15 | PXD015552 | Pride
C. elegans Mediator complex 
ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
TranscriptomicsTranscriptional profiling of ICAM-positive and -negative cells from the mouse olfactory epithelium
We used trasncriptional profiling of fluorescent activated cell sorting (FACS) purified ICAM1-positive and negative cells from the olfactory epithelium (OE) of three-week old mice to identify genes enriched in the horizontal basal cells. The olfactory epithelia from P21-P25 CD1 mice (Charles River L...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-31972 | biostudies-arrayexpress
UnknownA Novel CARMIL2 Immunodeficiency Identified in a Subset of Cavalier King Charles Spaniels with Pneumocystis and Bordetella Pneumonia.
Not available
S-EPMC10970956 | biostudies-literature
TranscriptomicsAnalysis of the placental tissue transcriptome from normal and testosterone treated rat pregnancy
Elevated testosterone levels increase maternal blood pressure and decrease uterine blood flow in pregnancy, resulting in abnormal perinatal outcomes. The placenta is the key in understanding the pathophysiological processes associated with pregnancy. The current study is designed to characterize the...
ORGANISM(S): Rattus norvegicus 
2015-04-20 | E-GEOD-61543 | biostudies-arrayexpress
TranscriptomicsSOX11-positive and SOX11-knockdown xenograft derived tumor Gene Expression Profilings
The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL). We have recently demonstrated SOX11 tumorigenic potential in vivo by showing a significant reduction on tumor growth of SOX11-knockdown MCL cells in xenograft experiments, co...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-52892 | biostudies-arrayexpress
TranscriptomicsMulti-modal proteomic target discovery and orthogonol confirmation of preclinical diabetic retinopathy drug development biomarkers
The aim of this study was to identify proteomic alterations associated with functional dysregulation of the retina with diabetes that could eventually be used as surrogate endpoints in preclinical drug testing studies. A multi-modal approach of antibody (Luminex)-, electrophoresis (2-DIGE)-, and LC-...
ORGANISM(S): Rattus norvegicus 
2010-06-01 | E-GEOD-20886 | biostudies-arrayexpress
Transcriptomics5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (liver)
Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and w...
ORGANISM(S): Rattus norvegicus 
2012-07-24 | GSE39525 | GEO
Transcriptomics5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum)
Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and w...
ORGANISM(S): Rattus norvegicus 
2012-08-04 | GSE39850 | GEO
UnknownParticipating in an International Stereotactic Radiotherapy Patient Registry: The Establishment of Data Collection Pathways.
Not available
S-EPMC5574631 | biostudies-literature
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