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ProteomicsRHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
To further investigate which molecules interact with RHOF in AML，we performed a comparative proteomic analysis of 293T cells overexpressing RHOF and control cells using liquid chromatography‒mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD052126 |
TranscriptomicsSkeletal muscle gene expression in response to resistance exercise: sex specific regulation
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exercise. We u...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-24235 | biostudies-arrayexpress
TranscriptomicsSex and aging effect on skeletal muscle transcriptome in humans
The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex. Muscle biopsies were obtained from the biceps brachii of young (age 19~28yrs) and older (age 65~76 yrs) men (7 young, 4 older) and women (7 young,...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-38718 | biostudies-arrayexpress
TranscriptomicsAPOL1 renal-risk variants induce mitochondrial dysfunction (Illumina)
To elucidate pathways whereby apolipoprotein L1 gene (APOL1) G1 and G2 variants facilitate kidney disease in African Americans, human embryonic kidney cells (HEK293) were used to establish doxycycline-inducible (Tet-on) cell lines stably expressing reference APOL1 G0 and its G1 and G2 renal-risk var...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-85918 | biostudies-arrayexpress
TranscriptomicsWidespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four color...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-63601 | biostudies-arrayexpress
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