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ProteomicsHuman Stomach normal and gastric cancer cells LC-MSMS
Metabolic reprogramming is a critical driver in the pathogenesis of gastric cancer (GC). However, the intricate regulatory mechanisms that govern this reprogramming and their role in GC progression remain inadequately understood. Here, we have elucidated that Methyltransferase-like 10 (METTL10) is a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD057247 | Pride
Human Lc-msms Stomach 
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (2)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
2025-09-22 | PXD068649 |
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (1)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
2025-09-22 | PXD068622 |
ProteomicsCleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059365 |
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