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ProteomicsStructural insights into regulatory mechanism of RNA modification by human m6A-METTL associated complex
N6-methyladenosine (m6A) is the most abundant ribonucleotide modification among the eukaryotic messenger RNAs (mRNAs). The m6A “writer” is composed of an m6A-METTL complex (MAC), the catalytic subunit, and an m6A-METTL associated complex (MACOM), the regulatory subunit essential for the enzymatic ac...
ORGANISM(S): Homo Sapiens 
2022-06-23 | PXD028456 |
ProteomicsStructural insights into dsRNA processing by Drosophila Dicer-2/Loqs-PD
Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA silencing mechanism in many eukaryotes. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), plays major role in generating 21 base-pair (bp) siRNA duplex...
ORGANISM(S): Drosophila Melanogaster 
2022-04-21 | PXD033365 |
ProteomicsCross-Link of mouse SPO11 and TOP6BL
Use XL-MS to detect whether SPO11 and TOP6BL can form heterotetramer
ORGANISM(S): Mus Musculus 
2024-11-28 | PXD058354 |
ProteomicsIdentification of the methyl-CpG binding protein 2 (MeCP2) interacting proteins in the high molecular weight (HMW) extract prepared from the human HEK293T cells by immunoprecipitation coupled with mass spectrometry analysis
Identification of MeCP2 interacting proteins in HMW extract of HEK293T cells
ORGANISM(S): Homo Sapiens 
2021-08-30 | PXD021650 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation
dNxf2 directly interacts with dNxf1 to compete with its binding to NPC
ORGANISM(S): Drosophila Melanogaster 
2019-08-01 | PXD014884 |
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