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TranscriptomicsIM002, IM009 - Implication of inflammatory macrophages, nuclear receptors and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation
While pandemic 2009 H1N1 influenza A viruses were responsible for numerous severe infections in humans, these viruses do not typically cause corresponding severe disease in mammalian models. However, the generation of a virulent 2009 H1N1 virus following serial lung passage in mice has allowed for t...
ORGANISM(S): Mus musculus 
2012-03-08 | E-GEOD-36328 | biostudies-arrayexpress
TranscriptomicsIdentification of pro-fibrotic macrophages populations by scRNA-seq in West Highland white terriers affected with canine idiopathic pulmonary fibrosis
We used the scRNA-seq to characterize disease-related heterogeneity within cell populations of macrophages/monocytes in the bronchoalveolar lavage fluid from West Highland white terriers either healthy or affected with canine idioapthic pulmonary fibrosis. The disease is still not well understood, o...
ORGANISM(S): Canis lupus familiaris 
2020-12-02 | E-MTAB-9623 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the potato (Solanum tuberosum L.) plant response to moderately elevated temperature
Although significant work has been undertaken regarding the response of model and crop plants to heat shock during the acclimatory phase, few studies have examined the steady state response to the mild heat stress encountered in temperate agriculture. In the present work we therefore exposed tuberis...
ORGANISM(S): Solanum tuberosum 
2013-08-01 | E-MTAB-1655 | biostudies-arrayexpress
MetabolomicsA multiplatform metabolomic approach to characterize fecal signatures of stressful postnatal events in chicks: a pilot study
Negative experiences in early life can induce long-lasting effects on the welfare, health, and performance of farm animals. A delayed placement of chicks in breeding houses has negative effects on their performance, and results in fecal-specific odours detectable by rats. Based on this observation, ...
2019-04-11 | MTBLS763 | MetaboLights
ProteomicsLC/MS/MS Analyses of enriched ECM-enriched preparations from planaria
ECM isolation - Whole-mount planarian decellularization has been optimized based on a previous publication (Sonpho et al. 2020). We optimized three protocols for decellularization, which we refer to as No Pretreatment ECM (NP-ECM), Formaldehyde ECM (FA-ECM), and N-Acetyl Cysteine pretreatment (NAC-E...
ORGANISM(S): Schmidtea Mediterranea (ncbitaxon:79327) 
2021-03-15 | MSV000087054 | MassIVE
TranscriptomicsTranscription profiling of yeast treated with rapamycin in a 7-part time series
This experiment was a 7-part time series (or, 2x7 factorial design) examining the effect of rapamycin on gene expression in Saccharomyces cerevisiae. Treated and untreated cultures were compared at 0, 20, 40, 60, 120, 240, and 360 minutes. In the paper, expression ratios (mRNA) at each time point ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-02-05 | E-TABM-639 | biostudies-arrayexpress
TranscriptomicsQuality control of transcription start site selection by Nonsense-Mediated-mRNA Decay
Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA quality-control pathway targeting transcripts such as messenger RNAs harboring premature stop-codons or short upstream open reading frame (uORFs). Our transcription start sites (TSSs) analysis of Saccharomyces cerevisiae cells deficie...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2015-04-24 | E-GEOD-64139 | biostudies-arrayexpress
TranscriptomicsTime-course RNA-Seq of ME3 cells as they undergo adipogenesis, with both control samples and samples treated with Isoproterenol
To identify and elucidate the mechanisms of adipogenic differentiation within the mouse 3t3-l1 cell line
ORGANISM(S): Mus musculus 
2019-11-26 | E-MTAB-8200 | biostudies-arrayexpress
UnknownCorrelating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.
Not available
S-EPMC3876788 | biostudies-literature
TranscriptomicsRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Irx3 was stably knocked out using a Crispr-Cas9 system. Cells were then input into a differentiation procedure, alongside controls, and RNA was collected for all samples.
ORGANISM(S): Mus musculus 
2019-11-26 | E-MTAB-8209 | biostudies-arrayexpress
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