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Phenotypic adaptation of Pseudomonas aeruginosa by hacking siderophores produced by other microorganisms

ABSTRACT: This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of exosiderophores in an epithelial cell infection assay. We show that the presence of exosiderophores induces the transcription and expression of their corresponding transporters, and that bacteria sense the presence of the chelators in their environment and adapt their phenotype to access iron via the exosiderophore present

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Pseudomonas Aeruginosa Pao1

TISSUE(S): Cell Culture

SUBMITTER: Paola Cantero

LAB HEAD: Laurence SABATIER

PROVIDER: PXD015638 | Pride | 2020-02-17

REPOSITORIES: Pride

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			Action	DRS
	A549_P. aeruguinosa.pride.mgf.gz	Mgf
	A549_P. aeruguinosa.pride.mztab.gz	Mztab
	A549_P.aeruguinosa.xml.gz	Xml
	QE21604LC.dat	Other
	QE21604LC.mgf	Mgf

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Publications

Phenotypic Adaption of Pseudomonas aeruginosa by Hacking Siderophores Produced by Other Microorganisms.

Perraud Quentin Q Cantero Paola P Roche Béatrice B Gasser Véronique V Normant Vincent P VP Kuhn Lauriane L Hammann Philippe P Mislin Gaëtan L A GLA Ehret-Sabatier Laurence L Schalk Isabelle J IJ

Molecular & cellular proteomics : MCP 20200205 4

Bacteria secrete siderophores to access iron, a key nutrient poorly bioavailable and the source of strong competition between microorganisms in most biotopes. Many bacteria also use siderophores produced by other microorganisms (exosiderophores) in a piracy strategy. Pseudomonas aeruginosa, an opportunistic pathogen, produces two siderophores, pyoverdine and pyochelin, and is also able to use a panel of exosiderophores. We first investigated expression of the various iron-uptake pathways ...[more]

PMID: 32024770

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