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MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
ProteomicsQuantitative Proteomics Reveal the Protective Effects of CuraUltra Against Alzheimer’s Disease via Modulating the Expression of Synapse-associated Proteins in Mouse Model
To identify the potential molecular mechanism responsible for the effect on CuraUltra treatment, label-free quantitative proteomics by tandem mass spectrometry (LC-MS / MS) were performed, which provides in depth characterization of protein profile changes . Critical altered proteins were validated ...
ORGANISM(S): Mus Musculus 
2021-11-10 | PXD029640 |
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsComprehensive Proteomic Profiling and Identification of Potential Hub Genes in Primary and Recurrent Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most lethal brain malignant neoplasm, associated with poor prognosis and high recurrence. The mechanisms involved in GBM development and recurrent remains largely unknown. Hence, it’s considerably imperative to explore the potential targets and unravel the mechan...
ORGANISM(S): Homo Sapiens 
2021-06-06 | PXD026503 |
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
PXD045174 |
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