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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
UnknownTraditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice.
Not available
S-EPMC7109517 | biostudies-literature
MetabolomicsArgR-dependent Bacterial Resistance to Host Lipid Droplets in Edwardsiella piscicida
Lipid droplets (LDs), as innate immune hubs, function in the front line of antimicrobial defense involved in the ongoing host-pathogen arms race. Particularly for intracellular bacterial pathogens, the endowed capacity to resist host LDs can effectively facilitate pathogen in vivo colonization and e...
2025-07-04 | MTBLS9590 | MetaboLights
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
UnknownHMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma.
Not available
S-EPMC5833394 | biostudies-literature
ProteomicsLC-MS/MS of an unidentified extracellular protein of Edwardsiella piscicida
This assay aims to identify the composition of an unidentified protein band (~10 kDa) in Edwardsiella piscicida’s extracellular proteins (ECPs). To make this end, this protein band was cut, followed by gel band excision and LC-MS/MS identification.
ORGANISM(S): Edwardsiella tarda EIB202 
2024-01-15 | PXD048313 | Pride
Lc-ms/ms Extracellular protein Edwardsiella piscicida 
ProteomicsLC-MS/MS of YfiD-interacting proteins in mammalian cells
To figure out the intracellular function of YfiD, HA-tagged YfiD or Mock was expressed in the HeLa cell line. Subsequently, the lysates of HeLa-YfiD or HeLa-Mock cells were immunoprecipitated with anti-HA beads followed by LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD047656 | Pride
Lc-ms/ms Yfid Mammalian cells 
UnknownTranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS): study protocol for a prospective, randomized, double-blind, non-inferiority trial.
Not available
S-EPMC6373130 | biostudies-literature
UnknownDeciphering the transcriptomic landscape of systemic lupus erythematosus-associated pulmonary arterial hypertension.
Not available
S-EPMC11921494 | biostudies-literature
UnknownThe role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
Not available
S-EPMC5897725 | biostudies-literature
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