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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsSKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis
Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transcriptional and posttranslational mechanisms are prominent in the basic network architecture of circad...
ORGANISM(S): Arabidopsis thaliana 
2012-12-13 | E-GEOD-32216 | biostudies-arrayexpress
MetabolomicsPlasma metabolomic profiling reveals altered metabolic pathways associated with idiopathic hyperaldosteronism
This study investigated plasma metabolic alterations associated with idiopathic hyperaldosteronism using untargeted liquid chromatography coupled with high-resolution mass spectrometry. Plasma samples from patients with idiopathic hyperaldosteronism and healthy controls were analyzed using a Vanquis...
2026-08-07 | MTBLS15210 | MetaboLights
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
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