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The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights

Systems biology is the study of complex living organisms, and as such, analysis on a systems-wide scale involves the collection of information-dense data sets that are representative of an entire phenotype. To uncover dynamic biological mechanisms, bioinformatics tools have become essential to fa...

2017-11-23 | MTBLS572 | MetaboLights
Cis-9, trans-11-conjugated linoleic acid (c9, t11-CLA), a functional fatty acid, is one of the research hotspots in the fields of functional dairy products development because of its multiple beneficial effects in humans and animals. In milk, most c9, t11-CLA is de novo synthesized from trans-11-oct...
ORGANISM(S): Bos taurus (Bovine) 
2022-08-12 | PXD028620 | Pride
Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mec...
ORGANISM(S): Homo sapiens 

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

2025-09-16 | MTBLS12716 | MetaboLights

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

2025-09-16 | MTBLS12715 | MetaboLights
Decreased salivary flow is one of the most common symptoms in primary Sjögren syndrome (pSS). The present study was designed to identify a salivary protein biomarker related to saliva secretion disorder in NOD/ShiLtJ mice, a pSS primary murine model. The stimulated saliva was collected from NOD/ShiL...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-21 | PXD008199 | Pride
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (~40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their content and isotope enrichment still represents a significant...
2025-06-16 | MTBLS12550 | MetaboLights
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