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TranscriptomicsRegulation of Gene Expression by Connective Tissue Growth Factor (CTGF) in Mesenchymal Stromal Cells (MSCs)
mRNA from bone marrow-derived MSCs stably expressing CTGF-specific shRNA (or empty vector control) was analyzed for differential gene expression. Significant differences were found in cell proliferation-related genes, especially genes related to the M phase of the cell cycle, which were down-regulat...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-47575 | biostudies-arrayexpress
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
TranscriptomicsTight Junction Protein 1 is a Modulator and Biomarker of Proteasome Inhibitor Sensitivity in Multiple Myeloma
Proteasome inhibitors are important chemotherapeutics in the treatment of multiple myeloma, but they are currently used empirically as no markers of sensitivity have been validated. We have identified expression of tight junction protein (TJP) 1 as being associated with sensitivity of plasma cells ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52369 | biostudies-arrayexpress
TranscriptomicsStudies in a murine B16 melanoma model show that persistent antigen at vaccination sites induces CD8+ T cell sequestration, dysfunction and deletion
To understand why cancer vaccine-induced T cells often fail to eradicate tumors, we studied immune responses in mice vaccinated with gp100 peptide emulsified in incomplete Freund's adjuvant (IFA), commonly used in clinical cancer vaccine trials. After gp100 peptide/IFA vaccination, tumor-specific CD...
ORGANISM(S): Mus musculus 
2013-03-02 | E-GEOD-43929 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of genes regulated by p44/wdr77 and PRMT5 in lung and prostate cancer cells
Analysis of gene expression in lung and prostate cancer cells expressing non-target (NT), p44/wdr77. or PRMT5 shRNA. Results provide important information on how p44/wdr77 and PRMT5 control cellular proliferation. Total RNA obtained from cells expressing NT, p44/wdr77, or PRMT5 shRNA.
ORGANISM(S): Homo sapiens 
2014-04-14 | E-GEOD-56757 | biostudies-arrayexpress
TranscriptomicsReciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation 1 of NF-κB mediates chemoresistance
Bone marrow (BM) mesenchymal stromal cells (BM-MSC) upregulate their NF-κB signaling to protect leukemia cells from chemotherapy-induced apoptosis. To elucidate molecular mechanisms by which leukemia-stroma interactions within the BM microenvironment could confer chemoresistance to leukemia cells, ...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-55533 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of tumor biopsies before and after pidilizumab therapy in patients with relapsed follicular lymphoma grade 1 or grade 2.
Endogenous or iatrogenic antitumor immune responses can improve the course of follicular lymphoma (FL), but may be diminished by immunoregulatory mechanisms in the tumor microenvironment. These may include effects of programmed death (PD)-1, a coinhibitory receptor that impairs T-cell function and i...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-52562 | biostudies-arrayexpress
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