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TranscriptomicsmicroRNA expression and opioid signaling
To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14268 | biostudies-arrayexpress
MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
UnknownTrio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.
Not available
S-EPMC6436967 | biostudies-literature
ProteomicsComparative proteomic analysis of porcine serum between experimental and control groups
This project contains LC-MS/MS-based proteomic data generated from porcine serum samples. Protein identification and quantitative analyses were performed to characterize the serum proteome and investigate differential protein expression among experimental groups.
ORGANISM(S): Sus Scrofa Domesticus 
2026-06-22 | PXD079982 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
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