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ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
ProteomicsHDX-MS studies on human and avian TRPM8 in response to menthol and cold
Thermosensitive TRP ion channels enable somatosensory nerve fibers to detect changes in our thermal environment over a wide physiologic range. In mammals, the menthol receptor, TRPM8, is activated by temperatures below ~26ºC and is essential for the perception of cold or chemical cooling agents. A f...
ORGANISM(S): Homo sapiens (Human) Pagrus major 
2026-03-25 | PXD064468 | Pride
Hdx-ms Thermosensation Ion channel Trpm8 
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