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ProteomicsHDX-MS studies on human and avian TRPM8 in response to menthol and cold
Thermosensitive TRP ion channels enable somatosensory nerve fibers to detect changes in our thermal environment over a wide physiologic range. In mammals, the menthol receptor, TRPM8, is activated by temperatures below ~26ºC and is essential for the perception of cold or chemical cooling agents. A f...
ORGANISM(S): Homo sapiens (Human) Pagrus major 
2026-03-25 | PXD064468 | Pride
Hdx-ms Thermosensation Ion channel Trpm8 
GenomicsApoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles
Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles
PRJNA1301392 | ENA
TranscriptomicsApoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles
During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3 ubiquitin ligase reg...
ORGANISM(S): Mus musculus 
2026-08-12 | GSE304502 | GEO
GenomicsAMTB, a TRPM8 Antagonist, Suppresses Growth and Metastasis of Osteosarcoma through Repressing the TGFβ Signaling Pathway
AMTB, a TRPM8 Antagonist, Suppresses Growth and Metastasis of Osteosarcoma through Repressing the TGFβ Signaling Pathway
PRJNA778237 | ENA
TranscriptomicsTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted by the neurons, and it aggravates colitis. However, the regulatory role of TRPM8 in SP relea...
ORGANISM(S): Rattus norvegicus 
2023-09-12 | GSE242559 | GEO
GenomicsTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
TRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
PRJNA1013943 | ENA
UnknownThe LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy.
Not available
S-EPMC9167300 | biostudies-literature
UnknownTargeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells.
Not available
S-EPMC5045378 | biostudies-literature
TranscriptomicsAMTB, a TRPM8 Antagonist, Suppresses Growth and Metastasis of Osteosarcoma through Repressing the TGFβ Signaling Pathway
Since its first identification in prostate cancers and prostate tissues, transient receptor potential melastatin-subfamily member 8 (TRPM8) is subsequently found to be overexpressed in a wide range of cancers and is shown to be implicated in tumorigenesis and tumor progression. Here, we used N-(3-am...
ORGANISM(S): Homo sapiens 
2024-11-01 | GSE188304 | GEO
UnknownRecent Progress in TRPM8 Modulation: An Update.
Not available
S-EPMC6600640 | biostudies-literature
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