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ProteomicsPACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Several large-scale genetic studies investigating the cause of neurodevelopmental disorders (NDDs) have been conducted, leading to the identification of hundreds of risk genes. However, our understanding of the mechanisms by which the observed genetic variants act has lagged, limiting translation of...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD080130 | Pride
Pacs1 Proteome Neurodevelopmental disorders Brain organoids 
TranscriptomicsLai_CMEW1_Cl_8
modENCODE_submission_2721 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their re...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-24307 | biostudies-arrayexpress
UnknownDeciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.
Not available
S-EPMC5931475 | biostudies-literature
UnknownMolecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni.
Not available
S-EPMC3757052 | biostudies-literature
GenomicsRLPII_phospho2_ab5095.Clone_8.Solexa
modENCODE_submission_5576 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of 125 chromosomal proteins across the Drosophila melanogaster genome. The proteins under s...
ORGANISM(S): Drosophila melanogaster 
2013-07-03 | E-GEOD-48513 | biostudies-arrayexpress
UnknownA functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.
Not available
S-EPMC5579262 | biostudies-literature
UnknownCan Iron Treatments Aggravate Epistaxis in Some Patients With Hereditary Hemorrhagic Telangiectasia?
Not available
S-EPMC5095791 | biostudies-literature
ProteomicsPhosphorylation of PABPN1 during mitosis protects mRNA from hyperadenylation and maintains transcriptome stability.
Polyadenylation controls mRNA biogenesis, nuclear export, translation, and decay. These processes are interdependent and coordinately regulated by several poly(A)-binding proteins (PABPs). How PABPs are functionally regulated to control RNA fate is not fully understood. Here, we show that human PABP...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD047110 | Pride
3′ end processing factors  polyadenylation Pabpn1 Rna stability Cell cycle Long-read sequencing 
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
UnknownCorrelations between the Composition of the Bovine Microbiota and Vitamin B12 Abundance.
Not available
S-EPMC7055655 | biostudies-literature
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