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TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
ProteomicsDrug sensitivity, gene dependency and proteogenomic correlates of the spectrum of telomere maintenance mechanisms in cancer cells
Replicative immortality is a hallmark of cancer, driven by activation of telomere maintenance mechanisms (TMM), that is yet to be therapeutically exploited. To expedite discoveries that will enable development of TMM-targeted therapeutics, we have generated a resource of telomere biology metrics for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD058664 | Pride
Tmm Cancer Proteomics Swath-dia Telomere biology 
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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