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Breast tumors are produced by an uncontrollable cell proliferation mechanism and can be classified as benign (TMB) or malignant (TMM). TMM or breast cancer is the neoplasia with the highest incidence and mortality in Mexican women. Over time, some types of TMB can transform into a TMM. However, the ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD019334 | Pride
This study compared whole transcriptome signatures of 6 immune cell subsets and whole blood from patients with an array of immune-associated diseases. Fresh blood samples were collected from healthy subjects and subjects diagnosed type 1 diabetes, amyotrophic lateral sclerosis, and sepsis, as well a...
ORGANISM(S): Homo sapiens 
Identification of human T cells that recognize a mycobacterial adjuvant, trehalose monomycolate (TMM)
Identification of CD1b-restricted human T cells recognizing a mycobacterial adjuvant, trehalose monomycolate (TMM)
Mycobacterium tuberculosis causes tuberculosis (TB) which remains one of the world’s deadliest diseases. As mycobacteria are protected by its thick lipid cell wall, the host has developed immune systems targeting their unique lipids. Among them is an unconventional T cell subset called mycolipid-spe...
ORGANISM(S): Homo sapiens 
2025-02-14 | GSE260931 | GEO
Mycobacterium tuberculosis (M. tb) causes tuberculosis (TB) which remains one of the world’s deadliest diseases. As M.tb are protected by its thick lipid cell wall, the host has developed specific immune receptors that recognize their unique lipids as antigens. Among them is a mycolipid-specific T c...
ORGANISM(S): Homo sapiens 
2025-02-14 | GSE261269 | GEO
Replicative immortality is a hallmark of cancer, driven by activation of telomere maintenance mechanisms (TMM), that is yet to be therapeutically exploited. To expedite discoveries that will enable development of TMM-targeted therapeutics, we have generated a resource of telomere biology metrics for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD058664 | Pride
To investigate possible smRNAs linked to TMM silencing by single-stranded and double-stranded silencers, we determined sequences of smRNAs by the Illumina high-throughput sequencing platform and compared silencing efficiency of different strategies. We found that single-stranded silencer alone could...
ORGANISM(S): Arabidopsis thaliana 
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