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ProteomicsExamining differential protein expression in brain and retinal tissue from the Mthfr677C>T mouse model
The Mthfr677C>T variant is associated with Alzheimer's disease and vascular dementia. We created a knockin mouse model containing the variant and have been characterizing brain and retinal health in the mice, with special focus on vascular dysfunction. We have shown similar vascular phenotypes in th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD062631 | Pride
Vascular contributions to cognitive impairment and dementia (vcid) Mouse model characterization Brain Neurovascular dysfunction Retina 
ProteomicsGenetic context modulates aging and degeneration in the murine retina
This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging sig...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD057861 | Pride
Genetic diversity Proteomics Retinal vascular disease Tmt Wsb Retinitis pigmentosa Nzo Aging Retina Diabetic retinopathy Lc-ms/ms 
TranscriptomicsTranscription profiling of Arabidopsis klu-2 mutants vs. wild type
The Arabidopsis cytochrome P450 KLUH (KLU)/CYP78A5 promotes organ growth in a non-cell autonomous manner. To identify genes regulated by KLU activity, homozygous klu-2 mutants carrying constructs for EtOH-inducible overexpression of wild-type KLU (35S::AlcR-AlcA::KLU) or of enzymatically inactive KL...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-9201 | biostudies-arrayexpress
UnknownBundled Consent in US Intensive Care Units.
Not available
S-EPMC7565087 | biostudies-literature
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
TranscriptomicsATAC-seq of control and Cyp26b1KO HSCs
The open chromatin of mouse control and Cyp26b1KO longterm hematopoietic stem cells has been profiled by ATAC-seq.
ORGANISM(S): Mus musculus 
2021-11-02 | E-MTAB-9778 | biostudies-arrayexpress
UnknownClimate change alters temporal dynamics of alpine soil microbial functioning and biogeochemical cycling via earlier snowmelt.
Not available
S-EPMC8319178 | biostudies-literature
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsAutomating Multidimensional Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry Data Analyses Using Skyline
Recent advances in ion mobility spectrometry (IMS) have illustrated its power in the structural characteristics of a molecule, especially when coupled with other separations dimensions such as liquid chromatography (LC) and mass spectrometry (MS). However, these three separation techniques together ...
ORGANISM(S): Bos Taurus Saccharomyces Cerevisiae 
PXD010650 | panorama
UnknownA Framework for Quality Control in Quantitative Proteomics.
Not available
S-EPMC11973981 | biostudies-literature
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