MacLeod Annette A

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Transcriptomics (3)
Metabolomics (1)
Genomics (1)

Organisms

Trypanosoma brucei gambiense (1)
Trypanosoma brucei brucei (1)
Mus musculus (1)

Repository

biostudies-arrayexpress (3)
MetaboLights (1)
ENA (1)

Technology Type

Mass spectrometry (1)

Instrument Platform

Liquid Chromatography MS - alternating - hilic (1)

Publication Date

2010 (2)
2011 (1)
2021 (1)

CHEBI ID

CHEBI:183219 (1)
CHEBI:183218 (1)
CHEBI:183216 (1)
CHEBI:183215 (1)
CHEBI:183214 (1)
CHEBI:183213 (1)
CHEBI:183212 (1)
CHEBI:183211 (1)
CHEBI:159047 (1)
CHEBI:183210 (1)
CHEBI:183209 (1)
CHEBI:16702 (1)
CHEBI:183208 (1)
CHEBI:162444 (1)
CHEBI:183206 (1)
CHEBI:183205 (1)
CHEBI:183204 (1)
CHEBI:166549 (1)
CHEBI:183203 (1)
CHEBI:183202 (1)
CHEBI:183201 (1)
CHEBI:137285 (1)
CHEBI:183199 (1)
CHEBI:183198 (1)
CHEBI:28470 (1)
CHEBI:183196 (1)
CHEBI:160450 (1)
CHEBI:183195 (1)
CHEBI:183194 (1)
CHEBI:183193 (1)

Metabolite Name

1,2-diheptadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) (1)
1-18:0-2-18:2-monogalactosyldiacylglycerol (1)
Glu-Glu-Tyr-Tyr (1)
Asn-Met-Asn-His (1)
Asn-Pro-Ser-Ser (1)
Asp-Phe-Pro-His (1)
1-(O-alpha-D-mannopyranosyl)-29-keto-(3R,31R)-dotriacontanediol (1)
Ovothiol A (1)
1-octadecanoyl-2-nonadecanoyl-sn-glycero-3-phosphoserine (1)
PA(O-18:0/20:1(11Z)) (1)
Arg-Lys-Met-Phe (1)
L-rhamnitol (1)
Gln-Pro-Ser (1)
2-Phenylethanolglucuronide (1)
(-)-2-((3,5-Dihydroxy-4-methoxyphenyl)methyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (1)
2-Phthalimidoglutaricacid (1)
Ser-Ser-Ser-Ser (1)
Arg-Phe-Phe-Asn (1)
Gamma-butyrolactone (1)
P-DPD (1)
Ala-Met-Met-Tyr (1)
PG(19:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (1)
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(1,3-dihydroxy-propyl-2-amine) (1)
2-hydroxy-tetracosanoic acid (1)
Met-Thr-Thr-Tyr (1)
Lys-Val-Val (1)
PE(44:5) (1)
Cys-Leu-Phe-Cys (1)
(+)-Adlumine (1)
Methylacetoin (1)

First Public Date

2013 (1)

Study type

RNA-seq of coding RNA (2)
Transcription profiling by array (1)

Release Date

2010 (2)
2011 (1)

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Parasite strain-specific pathogenesis in murine infections with Trypanosoma brucei

Different strains of T. brucei induce different degrees of pathology in infected animals, and TREU927-infected mice display greater splenomegaly and anaemia than 247-infected mice. The analysis of differential host gene expression in infected spleens has allowed the identification of which pathways ...

ORGANISM(S): Mus musculus

2010-03-03 | E-GEOD-17049 | biostudies-arrayexpress

Transcriptome analysis of two life cycle stages of Trypanosoma brucei gambiense

Trypanosoma brucei gambiense is the causative agent of the fatal human disease African sleeping sickness. Here we have compared the transcriptome of two different life cycle stages, the potentially human-infective bloodstream form and the non-human-infective procyclic stage, using digital gene expre...

ORGANISM(S): Trypanosoma brucei gambiense

2010-07-21 | E-GEOD-18065 | biostudies-arrayexpress

Genomic_diversity_of_Trypanosoma_brucei

PRJEB2486 | ENA

Transcriptome analysis of Cymelarsan resistant and Cymelarsan sensitive strains of Trypanosoma brucei.

A drug sensitive stock of T.b.brucei (STIB247) was used to generate a drug resistant strain (247MelCyR), expressing 130-fold increase in resistance to the melaminophenyl arsenical Cymelarsan (MelCy) by subcurative treatment in mice. Expression of the Cymelarsan resistant phenotype was maintained in...

ORGANISM(S): Trypanosoma brucei brucei

2011-07-28 | E-GEOD-23288 | biostudies-arrayexpress

Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole

Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the start of the century, and sustainable...

2021-11-02 | MTBLS2559 | MetaboLights

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