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The archetypal Th2 cytokine interleukin 4 (IL-4) has previously been shown to alternatively activate dendritic cells (DCs) both in vitro and in vivo.To more fully understand the impact of IL-4 dependent alternative activation of DCs, we used mRNA microarrays to define their transcriptional profile. ...
ORGANISM(S): Mus musculus 
Data from our group has shown that the protozoan parasite Trypanosoma brucei brucei can invade the mouse female reproductive tract (FRT) causing changes in tissue architecture and immune profile, as well as inducing reproductive cycle arrest. The purpose of this experiment was to identify transcript...
ORGANISM(S): Mus musculus 
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and are widely used to study protein function in cultured mammalian cells. Here, we develop CRISPR-engineered mouse lines that enable rapid and highly specific degradation of tagged endogenous proteins in vivo. Most...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-07 | PXD032374 | Pride
To identify genome-wide differentially expressed microRNAs (miRNAs) between Huntington's disease (HD) and control Human pre-frontal cortex samples
ORGANISM(S): Homo sapiens 
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