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ProteomicsSodium valproate is protective in a transgenic zebrafish model of Machado Joseph disease
The neurodegenerative disease Machado Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal disease that impairs control and co-ordination of movement. MJD is caused by expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, encoding a long polyglutamine (polyQ) reg...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-08-23 | PXD009612 | Pride
Ataxin-3 Label-free quantitative proteomics Machado joseph disease Polyq Zebrafish 
ProteomicsTreatment with sodium butyrate has therapeutic benefits for Machado-Joseph disease through the induction of autophagy
Machado-Joseph disease (MJD) is a fatal neurodegenerative disease caused by expansion of the trinucleotide repeat region within the ATXN3/MJD gene. Mutation of ATXN3 causes formation of neurotoxic ataxin-3 protein aggregates, neurodegeneration and motor deficits. Here we investigated the therapeutic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD024626 | Pride
Autophagy Trinucleotide repeat disease Label-free proteomics Spinocerebellar ataxia 3 Flow cytometry Sodium butyrate Microbiota Machado-joseph disease Polyq Neurodegeneration Zebrafish 
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownSodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo.
Not available
S-EPMC8377983 | biostudies-literature
UnknownUPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment.
Not available
S-EPMC12284258 | biostudies-literature
UnknownGenomic analysis of mouse retinal development.
Not available
S-EPMC439783 | biostudies-literature
UnknownTissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Not available
S-EPMC7494054 | biostudies-literature
UnknownDanazol treatment for telomere biology disorders: long-term results of a phase 1/2 study.
Not available
S-EPMC12805271 | biostudies-literature
UnknownMolecular Survey of Anaplasmataceae Agents, <i>Rickettsia</i> spp., <i>Bartonella</i> spp., and Piroplasmids in Ectoparasites from Cave-Dwelling Bats in Mainland Portugal.
Not available
S-EPMC11946244 | biostudies-literature
UnknownCentral Ghrelin Resistance Permits the Overconsolidation of Fear Memory.
Not available
S-EPMC5447505 | biostudies-literature
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