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ProteomicsSARS_CoV-2 substrate profiling in interferon-treated BEAS-2B cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease and to investigate whether 3CLpro cleavage of cellular substrates dampens host antiviral responses induced by type I interferons, we treated BEAS-2B cells with interferon-alpha (N = 3), interferon-beta (N = 3), or vehicle...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026815 | Pride
Bruker q-tof Sars-cov-2 3clpro Interferon Byonic Lung Tails 
ProteomicsSARS_CoV-2 substrate profiling in HEK-293 cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease by exposingnative proteome extracts from human embryonic kidney (HEK-293) cells (N = 3) to 3CLpro cleavage. Then, N Terminal Amine Labeling of Substates (TAILS) was used to identify the substrates. Here, heavy [+34] isoto...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026797 | Pride
Bruker q-tof Sars-cov-2 Covid19 Tails-n-terminomics 3clpro Nsp5 
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