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ProteomicsSARS_CoV-2 substrate profiling in interferon-treated BEAS-2B cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease and to investigate whether 3CLpro cleavage of cellular substrates dampens host antiviral responses induced by type I interferons, we treated BEAS-2B cells with interferon-alpha (N = 3), interferon-beta (N = 3), or vehicle...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026815 | Pride
Bruker q-tof Sars-cov-2 3clpro Interferon Byonic Lung Tails 
ProteomicsSARS_CoV-2 substrate profiling in HEK-293 cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease by exposingnative proteome extracts from human embryonic kidney (HEK-293) cells (N = 3) to 3CLpro cleavage. Then, N Terminal Amine Labeling of Substates (TAILS) was used to identify the substrates. Here, heavy [+34] isoto...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026797 | Pride
Bruker q-tof Sars-cov-2 Covid19 Tails-n-terminomics 3clpro Nsp5 
Genomics
Sequencing of 3CLpro SARS-CoV-2 mutants
PRJNA925007 | ENA
UnknownProgress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds.
Not available
S-EPMC9015912 | biostudies-literature
UnknownFlavonoids with inhibitory activity against SARS-CoV-2 3CLpro.
Not available
S-EPMC7470085 | biostudies-literature
UnknownDiscovery of 3CLpro inhibitor of SARS-CoV-2 main protease.
Not available
S-EPMC10116374 | biostudies-literature
UnknownBRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery.
Not available
S-EPMC9430692 | biostudies-literature
UnknownDevelopment of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Not available
S-EPMC9885526 | biostudies-literature
ProteomicsSupersulphide airway protection in viral and chronic lung diseases
Supersulphides (inorganic and organic sulphides with sulphur catenation) manifest diverse physiological functions. These supersulphides are mainly generated from mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here we found power...
ORGANISM(S): Escherichia coli 
2023-07-14 | PXD043607 | Pride
3clpro Plpro Spike protein 
UnknownLong-range cooperative interactions modulate dimerization in SARS 3CLpro.
Not available
S-EPMC2570436 | biostudies-literature
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