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ProteomicsCoronavirus PLPro interactome AP-MS data
Main proteases and papain-like proteases (PLpro) are essential coronaviral enzymes required for polypeptide processing during viral maturation. PLpro additionally cleave host cellular proteins to evade anti-viral immune responses. Here, we provide biochemical, structural and functional characterizat...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD018983 | Pride
Isgylation Ap-ms Sars-cov-2 Plpro 
ProteomicsGlobal ISGylome analysis to identify substrates of SARS-CoV-2 Nsp3-PLpro
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins (ISGylation). Several viruses, including SARS-CoV-2, reverse the process of protein ISGylation by encoding specialized enzymes harboring deISGylating enzymati...
ORGANISM(S): Homo sapiens (Human) 
2026-05-05 | PXD068808 | Pride
Sars-cov-2 Plpro Isg15 Deisgylation Isgylome Lc-ms/ms 
ProteomicsProteome-wide identification of ISG15 sites targeted by SARS-CoV-2 PLpro
Here, we applied an ISG15-GlyGly peptidomics approach on HeLa cells producing high levels of ISGylated proteins upon stimulation with IFN-α. After obtaining cellular lysates from wild-type and Isg15-/-cells, the samples were incubated with recombinant wild-type or mutant PLpro to catalyze deISGylati...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD026748 | Pride
Interferon Sars-cov-2 Isg15 
UnknownInhibitors of SARS-CoV-2 PLpro.
Not available
S-EPMC9086436 | biostudies-literature
TranscriptomicsGene expression profiling of HBEpCs and Caco-2 cells during infection with WT SARS-CoV-2 or a recombinant SARS-CoV-2 deficient in PLpro deISGylation activity
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins, a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the direct targets and ...
ORGANISM(S): Homo sapiens 
2026-05-08 | GSE308448 | GEO
ProteomicsBiochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging to characterize. Encoded within the multidomain Nsp3 is the papain-like proteas...
ORGANISM(S): Homo sapiens (Human) 
2021-09-15 | PXD022904 | Pride
Ubiqutylation Isg15 Sars cov-2 
UnknownMechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Not available
S-EPMC7461020 | biostudies-literature
UnknownIdentification of Doxorubicin as Repurposing Inhibitory Drug for MERS-CoV PLpro.
Not available
S-EPMC9654812 | biostudies-literature
UnknownInhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants.
Not available
S-EPMC12155308 | biostudies-literature
UnknownDesign of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.
Not available
S-EPMC8547495 | biostudies-literature
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