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UnknownStrategies to Identify Recognition Signals and Targets of SUMOylation.
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S-EPMC3395311 | biostudies-literature
ProteomicsGlobal ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
Mutations in PINK1 and Parkin lead to Parkinson’s disease. Cell culture-based studies have demonstrated that mitochondrial depolarisation induced by chemical uncouplers can activate PINK1 and Parkin activity. Very little is known on mitochondrial depolarisation signalling in post-mitotic neurons. We...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD027614 | Pride
Ubiqutylation Parkinsosn's disease Protoemics Pink1 
ProteomicsBiochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging to characterize. Encoded within the multidomain Nsp3 is the papain-like proteas...
ORGANISM(S): Homo sapiens (Human) 
2021-09-15 | PXD022904 | Pride
Ubiqutylation Isg15 Sars cov-2 
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