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ProteomicsGlobal ISGylome analysis to identify substrates of SARS-CoV-2 Nsp3-PLpro
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins (ISGylation). Several viruses, including SARS-CoV-2, reverse the process of protein ISGylation by encoding specialized enzymes harboring deISGylating enzymati...
ORGANISM(S): Homo sapiens (Human) 
2026-05-05 | PXD068808 | Pride
Sars-cov-2 Plpro Isg15 Deisgylation Isgylome Lc-ms/ms 
UnknownThe in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.
Not available
S-EPMC6879477 | biostudies-literature
ProteomicsMDA-MB-231 MS analysis of ISGylome, GDI2 interactome and total proteome changes in different ISGylation models
Analysis of ISG15 conjugation (Isgylation)role as driver of poor prognosis in non HER2+ breast cancer tumours. The project includes an analysis of total proteome and ISGylome characterization of MDA-MB-231 cells, wild-type or knock-out for the ISGyltaion associated genes, ISG15, UBE2L6 and USP18. Ad...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025753 | Pride
Breast cancer Gdi2 Egfr recycling Isg15 
ProteomicsUSP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
The interferon Stimulated Gene-15 (ISG15) is a ubiquitin-like modifier induced by type I Interferon (IFN-I) and plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade through a process called ISGylation. While USP18...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD055843 | Pride
Human Innate immunity Ubiquitomics Isg15 Immunology Usp24 
ProteomicsDeep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
The deubiquitylating enzyme USP18 is a major negative regulator of the interferon (IFN) signalling cascade. IFN pathways contribute to resistance to conventional chemotherapy, radiotherapy, and immunotherapy and are often upregulated in certain tumours, including breast, lung, and colon tumours. USP...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018299 | Pride
Human Cancer Deisgylating enzyme Proteomics Usp18 Isg15 Immunotherapy 
UnknownCellular targets and lysine selectivity of the HERC5 ISG15 ligase.
Not available
S-EPMC10831901 | biostudies-literature
ProteomicsProteomics-based identification of ISG15 modification sites during Listeria monocytogenes infection
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity, however its precise mechanism of action during viral or bacterial infection remains elusive. We previously found that ISG15 restricts Listeria infection both in vitro and in vivo and identified IS...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-28 | PXD011513 | Pride
Listeria infection Mice Isg15 Ubiquitin-like modification 
UnknownDeletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Not available
S-EPMC7884788 | biostudies-literature
ProteomicsProteome-wide identification of ISG15 sites in HeLa cells
We employed a GlyGly-peptidomics approach to comprehensively map ISG15 modification sites in HeLa cells under three conditions: mock-transfected controls, IFN-induced cells, and cells transfected with the ISGylation machinery. Lysates from wild-type and Isg15 knockout (KO) cells were processed using...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD065158 | Pride
Ptm Hela Glygly Isg15 Gg-peptidomics 
ProteomicsProteomics-based identification of ISG15 modification sites in vivo upon Coxsackie virus infection
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral activity against several clinically relevant viruses. However, its precise mechanism of action during viral infection remains elusive. Upon infection, ISG15 conjugates to protein substrates in covalent manner. We previously f...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2024-05-23 | PXD032078 | Pride
Mouse Virus Isg15 Infection Ubiquitin 
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