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Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
UnknownTargeting USP18 overcomes acquired resistance in hepatocellular carcinoma by regulating NCOA4 deISGylation and ferroptosis.
Not available
S-EPMC12166087 | biostudies-literature
UnknownParthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease.
Not available
S-EPMC9827819 | biostudies-literature
UnknownGasdermin-E-Dependent Non-Canonical Pyroptosis Promotes Drug-Induced Liver Failure by Promoting CPS1 deISGylation and Degradation.
Not available
S-EPMC11040357 | biostudies-literature
TranscriptomicsGene expression profiling of HBEpCs and Caco-2 cells during infection with WT SARS-CoV-2 or a recombinant SARS-CoV-2 deficient in PLpro deISGylation activity
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins, a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the direct targets and ...
ORGANISM(S): Homo sapiens 
2026-05-08 | GSE308448 | GEO
GenomicsGene expression profiling of HBEpCs and Caco-2 cells during infection with WT SARS-CoV-2 or a recombinant SARS-CoV-2 deficient in PLpro deISGylation activity
Gene expression profiling of HBEpCs and Caco-2 cells during infection with WT SARS-CoV-2 or a recombinant SARS-CoV-2 deficient in PLpro deISGylation activity
PRJNA1330611 | ENA
ProteomicsGlobal ISGylome analysis to identify substrates of SARS-CoV-2 Nsp3-PLpro
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to proteins (ISGylation). Several viruses, including SARS-CoV-2, reverse the process of protein ISGylation by encoding specialized enzymes harboring deISGylating enzymati...
ORGANISM(S): Homo sapiens (Human) 
2026-05-05 | PXD068808 | Pride
Sars-cov-2 Plpro Isg15 Deisgylation Isgylome Lc-ms/ms 
UnknownImpairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo.
Not available
S-EPMC7307143 | biostudies-literature
UnknownTwo independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.
Not available
S-EPMC3281662 | biostudies-literature
ProteomicsUSP18 interactor and PTM mass spectrometry
The ubiquitin-like protein ISG15 is activated in response to type 1 interferons and its conjugation to proteins regulates the response to bacterial and viral infection. Its subsequent deconjugation, by a single human enzyme, USP18, critically controls interferon signaling and the defense against pat...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058618 | Pride
Usp41 Isg15 Deisgylation Deubiquitinase Usp18 
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