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ProteomicsUSP18 interactor and PTM mass spectrometry
The ubiquitin-like protein ISG15 is activated in response to type 1 interferons and its conjugation to proteins regulates the response to bacterial and viral infection. Its subsequent deconjugation, by a single human enzyme, USP18, critically controls interferon signaling and the defense against pat...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058618 | Pride
Usp41 Isg15 Deisgylation Deubiquitinase Usp18 
TranscriptomicsMicroarray analysis to evaluate the function of USP18 in the mouse CNS
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, calle...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61499 | biostudies-arrayexpress
ProteomicsUSP18-dependent muscle proteome
USP18 is an interferon type 1 (IFN-1) induced gene that negatively regulates the IFN-1 signalling pathway, which plays a role in many immune related pathologies. Dermatomyositis (DM) is characterised by excessive IFN-1 immune response and muscle degeneration. We found USP18 to be expressed in DM myo...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032406 | Pride
Myogenesis Muscle cell differentiation Dermatomyositis Usp18 Skeletal muscle 
ProteomicsDeep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
The deubiquitylating enzyme USP18 is a major negative regulator of the interferon (IFN) signalling cascade. IFN pathways contribute to resistance to conventional chemotherapy, radiotherapy, and immunotherapy and are often upregulated in certain tumours, including breast, lung, and colon tumours. USP...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018299 | Pride
Human Cancer Deisgylating enzyme Proteomics Usp18 Isg15 Immunotherapy 
GenomicsUSP18 is an essential regulator of muscle cell differentiation and maturation
USP18 is an essential regulator of muscle cell differentiation and maturation
PRJNA816892 | ENA
ProteomicsA co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling
Type I interferon (IFN) signalling induces the expression of several hundred IFN-stimulated genes (ISGs) that provide an unfavourable environment for viral replication. To prevent an overexuberant response and autoinflammatory disease, IFN signalling requires tight control. One critical regulator is...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD051575 | Pride
Isgylation Isg15 Signalling Interferon 
UnknownMultiple functions of USP18.
Not available
S-EPMC5260889 | biostudies-literature
GenomicsUSP18 impacts on platinum-resistance in ovarian cancer cells by modulating DNA repair
USP18 impacts on platinum-resistance in ovarian cancer cells by modulating DNA repair
PRJNA1444006 | ENA
GenomicsSingle-cell transcriptomic analysis of tumor-infiltrated immune cells from myeloid-specific Usp18 knockout mice
Single-cell transcriptomic analysis of tumor-infiltrated immune cells from myeloid-specific Usp18 knockout mice
PRJNA726807 | ENA
TranscriptomicsUSP18 is an essential regulator of muscle cell differentiation and maturation
USP18 is an interferon type 1 (IFN-1) induced gene that negatively regulates the IFN-1 signalling pathway, which plays a role in many immune related pathologies. Dermatomyositis (DM) is characterised by excessive IFN-1 immune response and muscle degeneration. We found USP18 to be expressed in DM myo...
ORGANISM(S): Homo sapiens 
2022-03-23 | GSE198794 | GEO
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