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UnknownC-terminal processing of GlyGly-CTERM containing proteins by rhombosortase in Vibrio cholerae.
Not available
S-EPMC6219818 | biostudies-literature
ProteomicsGingipain transpeptidation - Porphyromonas gingivalis Gingipains Display Transpeptidation Activity
Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface proteases Lys-gingipain (Kgp) and Arg-gingipains (RgpA and RgpB) are major virulence factors and their proteolytic activity is enhanced by small peptides such as glycylgly...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009950 | Pride
Transpeptidation Hemoglobin Gingipains Porphyromonas gingivalis 
UnknownThe GlyGly-CTERM domain functions as an independent motif that targets proteins to rhombosortase in <i>Vibrio cholerae</i>.
Not available
S-EPMC12889589 | biostudies-literature
UnknownGlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine protease.
Not available
S-EPMC3237569 | biostudies-literature
ProteomicsUbiquitin diGly site ampping on ZNFX1 autoubiquitination reactions
This experiment aimed to characterise ubiquitin chain linkage preferences generated and autoubiquitination sistes during ZNFX1 E3 reactions using diGly remnant mass spectrometry. GlyGly-modified lysine residues were identified as a qualitative proxy for ubiquitin linkage types. Spectral counts of ra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD073484 | Pride
Znfx1 ubiquitin chains 
ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Identification of SUMO modified proteins from hiPS cells
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028050 | Pride
Sumo Hipsc Stem cells 
ProteomicsProteome-wide identification of ISG15 sites in HeLa cells
We employed a GlyGly-peptidomics approach to comprehensively map ISG15 modification sites in HeLa cells under three conditions: mock-transfected controls, IFN-induced cells, and cells transfected with the ISGylation machinery. Lysates from wild-type and Isg15 knockout (KO) cells were processed using...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD065158 | Pride
Ptm Hela Glygly Isg15 Gg-peptidomics 
ProteomicsMapping ISG15 sites in HeLa cells during MPXV virus infection
We applied an ISG15-GlyGly peptidomics approach to HeLa cells infected with monkeypox virus (MPXV). Cells were lysed in 5% SDS and processed using S-Trap columns. Following trypsin digestion, GlyGly-modified peptides were enriched and subsequently identified and quantified by LC–MS/MS. In addition, ...
ORGANISM(S): Monkeypox virus Homo sapiens (Human) 
2026-09-01 | PXD075835 | Pride
Mpxv Hela Isg15 
UnknownThe effect of antecedent hypoglycaemia on β₂-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the β₂-adrenergic receptor.
Not available
S-EPMC3071931 | biostudies-literature
UnknownIrreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Not available
S-EPMC5877979 | biostudies-literature
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