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ProteomicsPhosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membra...
ORGANISM(S): Rattus Rattus (black Rat) 
2026-07-31 | PXD080679 | JPOST Repository
TranscriptomicsCGH of common Candida albicans strains
The purpose of this review is to describe the tools used to detect genome changes, to highlight recent advances in our understanding of large scale chromosome changes that arise in C. albicans and to discuss the role of specific stresses in eliciting these genome changes. The types of genomic divers...
ORGANISM(S): Candida albicans 
2010-06-01 | E-GEOD-21643 | biostudies-arrayexpress
TranscriptomicsDifferences in the genomic content of Bordetella pertussis strains before and after vaccine introduction in European countries
Resurgence of pertussis has been observed in many countries with high vaccination coverage and clonal expansion of certain Bordetella pertussis strains has been associated with recent epidemics in Europe. It is known that vaccinations have selected strains which are different from those used for vac...
ORGANISM(S): Bordetella pertussis 
2011-10-03 | E-GEOD-29579 | biostudies-arrayexpress
TranscriptomicsClinical implications of gene dosage and gene expression patterns in diploid breast carcinoma (CGH)
Genomic and expression profiling using 38K BAC array-CGH and Illumina HT-12 beadchips were performed on 97 diploid invasive breast tumors to assess the impact of gene dosage on gene expression patterns and the effect of other mechanisms on transcriptional levels. Patient stratification was performed...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-20483 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of single circulating tumor cells with diagnostic intention
About 230 clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but no assays enable comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for CTC enrichment and isolation with 100% purity wit...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-58192 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
Epidermal growth factor (EGF) is a key regulatory growth factor activating a myriad of processes affecting cell proliferation and survival that are relevant to normal development and disease. Here we have used a combined approach to study the EGF dependent transcriptome of HeLa cells. We obtained mR...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-17403 | biostudies-arrayexpress
TranscriptomicsIdentification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (aCGH)
Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in > 50% of cases. Th...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-46284 | biostudies-arrayexpress
TranscriptomicsThe methylome of Alu repeats in colon cancer (CGH)
Next Generation Sequencing of Unmethylated Alu (NSUMA) interrogation of more than 130,000 individual Alus for differential methylation with concomitant analysis of copy number variations applied to the study of hypomethylation in colorectal cancer. normal colon tissues, matched primary tumors, and c...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-72750 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of gastroesophageal adenocarcinoma
We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas using 32k high-resolution arr...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-22524 | biostudies-arrayexpress
TranscriptomicsCGH analysis of Candida albicans strains
Aneuploidy and the evolution of aneuploid karyotypes of Candida albicans strains was identified using aCGH. Whole chromosome and segmental aneuploidies, (specifically on the left arm of chromosome 5 - shown to be due to isochromosome formation) are associated with the appearance of resistance to th...
ORGANISM(S): Candida albicans 
2006-06-30 | E-GEOD-4995 | biostudies-arrayexpress
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