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GenomicsComparing nodal versus bony metastatic spread using tumour phylogenies
The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metastatic spread, suggesting the possibility of distinct aetiologies. To explore this, we trace...
EGAS00001001801 | EGA
TranscriptomicsExpression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated CTL
In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to expl...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26290 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human Acute Myeloid Leukemia samples
Not available
ORGANISM(S): Homo sapiens 
2011-01-21 | E-TABM-978 | biostudies-arrayexpress
GenomicsTracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer ...
EGAS00001000942 | EGA
GenomicsSNP_dataset_1
Tissue samples using Illumina HumanOmniExpress-FFPE-12 v1.0 BeadChip
EGAD00010001179 | EGA
GenomicsDAC for the Prostate Cancer Lymph Node dataset
Data Access Committee EGAC00001000586
EGAC00001000586 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:03:14:947-502 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. Whole genome shotgun sequencing of fifteen samples, tumour and whole blood, from the four initial patients.
EGAD00001001343 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:06:47:615-508 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. RNA-seq of twelve samples, tumour and benign tissue, from the four initial patients.
EGAD00001001345 | EGA
Genomicsena-DATASET-UOM-CAP-21-04-2015-13:04:36:707-504 - samples
Data from the study of subclonal metastatic expansion in prostate cancer. Whole genome shotgun sequencing of six samples, tumour and whole blood, from the three additional patients whose somatic variants were examined in depth.
EGAD00001001344 | EGA
GenomicsDAC for integrated genomics of metastatic prostate cancer
Data Access Committee EGAC00001000230
EGAC00001000230 | EGA
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