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GenomicsDistribution of macroH2A1 nucleosomes in mouse liver chromatin
We produced a genome-wide map of the distribution of macroH2A1 histone variants in mouse liver chromatin using high-throughput sequencing of DNA from macroH2A1 nucleosomes. Although macroH2A1 nucleosomes are widely distributed across the genome, their local concentration varies over a range of 100-f...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-18963 | biostudies-arrayexpress
TranscriptomicsRNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54846 | biostudies-arrayexpress
GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
TranscriptomicsMacroH2A1 ChIP-chip
MacroH2A1 ChIP-chip was performed on custom Nimblegen genomic tiling arrays, to understand the genomic binding patterns of this histone variant and its relationship to gene expression Keywords: ChIP-chip Two macroH2A biological replicates are included. An H3 ChIP-chip sample is included as a control
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-9607 | biostudies-arrayexpress
TranscriptomicsMacroH2A1 ChIP-chip from IMR90 cells
MacroH2A1 is a histone variant that is enriched on the inactive X chromosome (Xi) in mammals and is postulated to play an important, but unknown, role in the repression of gene expression. Here we show that although macroH2A1 marks repressed autosomal chromatin, it positively regulates transcriptio...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18633 | biostudies-arrayexpress
ProteomicsA map of post-translational modifications of macroH2A1 splicing variants and their interactome
The aim was to characterize PTM of macroH2A1.1 and macro H2A1.2 by LC-MS/MS to facilitate the understanding of their distinct biological functions in health and disease. Next, the interactome of macroH2A1 isoforms was investigated to elucidate whether the two variants could differentially orchestrat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022968 | Pride
Histone Dna repair Human Lc-ms/ms 
GenomicsMacroH2A1 ChIP-seq from IMR90 human primary lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54845 | biostudies-arrayexpress
GenomicsmacroH2A1 ChIP-seq in G1/S phase and metaphase
macroH2A1 ChIP-seq in G1/S phase and metaphase
PRJNA979197 | ENA
GenomicsHuman cytomegalovirusinduces neuronal geneexpression to promote virionmaturationin macroH2A1-dependent manner​
Human cytomegalovirusinduces neuronal geneexpression to promote virionmaturationin macroH2A1-dependent manner​
PRJNA1135976 | ENA
UnknownDevelopmental changes in histone macroH2A1-mediated gene regulation.
Not available
S-EPMC1899912 | biostudies-literature
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