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MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
ProteomicsComaprison of the phagosome proteome of bone marrow-derived macrophages and RAW264.7
Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264.7 cell line is commonly used for experiments in the macrophage and phagocytosis field. However, little is known how its functions compare...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084938 | MassIVE
OtherHigh-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages.
Data from ProteomeXchange, PXD ID: PXD001293. File: BMDM_2.mzml. Published as part of Proteomics. 2014 Dec 12 . From the Abstract: {{i}} Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320007638 | GPMDB
Resource Reanalysis 
UnknownMacrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Not available
S-EPMC6282883 | biostudies-literature
ProteomicsQuantitative proteomic analysis of targeted degradation following Pep-TAC treatment
Quantitative proteomic analysis raw data for the manuscript entitled “A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy”.
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-01-22 | PXD060051 |
UnknownCryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.
Not available
S-EPMC4379045 | biostudies-literature
ProteomicsComprehensive proteome analysis reveals the central role of macrophage lysosomes in regulating immune responses
Phagocytosis and autophagy in macrophages have been shown to be essential to both innate and adaptive immunity. Lysosomes are the main catabolic subcellular organelles responsible for degradation and recycling of both extracellular and intracellular material, which are the final steps in phagocytosi...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-24 | PXD002915 | Pride
Innate immunity Proteomics Macrophage lysosome Pathogen 
UnknownThe macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Not available
S-EPMC6526827 | biostudies-literature
TranscriptomicsBeyond the Macrophage: System-wide Cellular and Molecular Dysregulation in GBA1 Deficient Mice Recapitulates Human Non-neuronopathic, Type 1 Gaucher Disease
In non-neuronopathic type 1 Gaucher disease (GD1) mutations in GBA1 gene results in deficiency of glucocerebrosidase and the accumulation of glucocerebroside in lysosomes of mononuclear phagocytes. The metabolic defect leads to a complex phenotype involving the viscera, the bone marrow and the skele...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-23086 | biostudies-arrayexpress
UnknownModulation of macrophage activities in proliferation, lysosome, and phagosome by the nonspecific immunostimulator, mica.
Not available
S-EPMC4323240 | biostudies-literature
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