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TranscriptomicsGenomic Collaboration of Estrogen Receptor-α and ERK2 in Regulating Gene and Proliferation Programs
The nuclear hormone receptor, estrogen receptor-alpha (ERα), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interact...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24592 | biostudies-arrayexpress
TranscriptomicsDevelopment of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation in Mice
There is great medical need for estrogens having favorable pharmacological profiles, supporting desirable activities for menopausal women such as metabolic and vascular protection but lacking stimulatory activities on the breast or uterus. Here, we report the development of structurally novel estrog...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-73663 | biostudies-arrayexpress
TranscriptomicsThe transcription factor FOXM1 coordinates the expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression
The transcription factor FOXM1 coordinates the expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We have previously shown that FOXM1 acts downstream of 14-3-3ζ signaling, which correlates with a more aggressive tumor phenotype. However, the role...
ORGANISM(S): Homo sapiens 
2014-08-07 | E-GEOD-55204 | biostudies-arrayexpress
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