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TranscriptomicsGrowth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity
Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Objective: to understand why many human thyroid cancer cell lines keep producing TTF-1 d...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-58587 | biostudies-arrayexpress
TranscriptomicsGrowth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity
Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Objective: to understand why many human thyroid cancer cell lines keep producing TTF-1 d...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-58243 | biostudies-arrayexpress
TranscriptomicsRevisiting the transcriptional analysis of primary tumors and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer
The biology underlying nodal metastasis is poorly understood. Transcriptome profiling has helped to characterize both primary tumors seeding nodal metastasis and the metastasis themselves. The interpretation of these data, however, is not without ambiguities. Here we profiled the transcriptomes of 1...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-60542 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in autonomous thyroid adenomas: correlation with mRNA regulation
MicroRNA (miRNA) are a class of small non-coding RNAs that act on the stability and the translation efficiency of their mRNA targets. Several evidences suggest that they play a role in tumorigenesis. So far, all types of thyroid tumors have been studied for miRNA expression except autonomous adenoma...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-33079 | biostudies-arrayexpress
TranscriptomicsmiRNA expression may account for chronic but not for acute regulation of mRNA expression in human thyroid tumor models
Background: For thyroid tumorigenesis, two main human in vitro models are available: primary cultures of human thyrocytes treated with TSH or EGF/serum as models for autonomous adenomas (AA) or papillary thyroid carcinomas (PTC) respectively, and human thyroid tumor derived cell lines. Previous work...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61482 | biostudies-arrayexpress
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