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TranscriptomicsExpression profile of the endocrine therapy resistant breast cancer cells LTED depleted of PBX1 or treated with the gamma-secretase inhibitor MRK003
Analysis of the response to PBX1 deprivation either using an siRNA approach or using a chemicalcompound indirectly targeting it. Deprivation of PBX1 is hypothesized to be essential for the growth of endocrine therapy resistant breast cancer cells (LTED) Total RNA was obtained from cells treated with...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-36928 | biostudies-arrayexpress
TranscriptomicsExpression profile of the endocrine therapy sensitive breast cancer cells MCF7 depleted of PBX1
Effect of PBX1 silencing on global gene expression of MCF7 cells stimulated with EGF. The hypothesis tested was that PBX1 is essential for EGF signaling in ERa positive breast cancer cells. Total RNA was obtained from MCF7 cells treated with siRNA directed at PBX1 or an siControl for 72h. Cells were...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39417 | biostudies-arrayexpress
TranscriptomicsGenome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39418 | biostudies-arrayexpress
GenomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [ChIP-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78284 | biostudies-arrayexpress
GenomicsThe pioneer factor PBX1 guides a distinct ERa signaling in breast cancer [ChIP-seq]
We profiled global PBX1 binding in MCF7 cells. The hypothesis tested was that PBX1 binds regions that recruit ERa following estradiol stimulation. Profiling of PBX1 cistrome in MCF7 breast cancer cells
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-28007 | biostudies-arrayexpress
TranscriptomicsThe pioneer factor PBX1 guides a distinct ERa signaling in breast cancer [mRNA profiling]
Effect of PBX1 silencing on global gene expression of MCF7 cells stimulated with estradiol. The hypothesis tested was that PBX1 is essential for estrogen signaling in ERa positive breast cancer cells. Total RNA was obtained from MCF7 cells treated with siRNA directed at PBX1 or an siControl for 72h....
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-28006 | biostudies-arrayexpress
TranscriptomicsThe pioneer factor PBX1 guides a distinct ERa signaling in breast cancer
This SuperSeries is composed of the following subset Series: GSE28006: The pioneer factor PBX1 guides a distinct ERa signaling in breast cancer [mRNA profiling] GSE28007: The pioneer factor PBX1 guides a distinct ERa signaling in breast cancer [ChIP-seq] Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-28008 | biostudies-arrayexpress
GenomicsDrug specific epigenetic reprogramming leads to increased cellular invasion in ERα positive breast cancer via de novo cholesterol biosynthesis.
Endocrine therapy resistance remains a critical problem in the treatment of estrogen receptor alpha (ERα) breast cancer. Endocrine therapies target ERα via different modes of action. Drug resistance involves drug specific remodeling of the transcriptional and regulatory landscape. Using epigenomic...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-60517 | biostudies-arrayexpress
GenomicsAPOBEC3B facilitates a functional and necessary link between estrogen receptor mediated transcription and DNA repair
Oestrogen receptor-α (ER) is the principal transcription factor in the majority of breast cancers, driving expression of genes that control cell growth and endocrine response. Understanding the mechanisms of ER action is crucial for improving response to endocrine treatments. Recent studies show tha...
ORGANISM(S): Homo sapiens 
2015-09-07 | E-GEOD-57426 | biostudies-arrayexpress
UnknownEngagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages.
Not available
S-EPMC10835215 | biostudies-literature
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