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GenomicsThe histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress
TranscriptomicsA nuclear-localized red fluorescence knock-in reporter allele for mouse pancreatic beta-cells
In this study, we generated a novel nuclear-localized red fluorescence knock-in reporter allele (Ins2.Apple) for mouse pancreatic beta-cells. Beta-cells were isolated by FACS from 60-day-old mice, segregated by sex, and RNA-sequencing was performed to assess sex-specific differences in beta-cell gen...
ORGANISM(S): Mus musculus 
2018-12-15 | E-MTAB-6329 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of Sox17.Epi and Endo cells in mouse embryos
This experiment has been done to understand the dynamics of gene expression in Sox17.Epi and Endo cells using multiplex RNA-Seq technology. Sox17.Epi (Sox17^GFP+EpCAM+) and Sox17.Endo (Sox17^GFP+EpCAM-) cells were isolated by FACS from E9.5 mouse embryos. The spatial comparison between Sox17.Epi ver...
ORGANISM(S): Mus musculus 
2012-07-20 | E-MTAB-970 | biostudies-arrayexpress
TranscriptomicsH3K27me3 profiles along the length of the X chromosome in trophoblast stem (TS) cells, ChIP-chip
This analysis includes H3K27me3 profiles along the length of the X-chromosome in male (F2) and female (K4) TS cells and in female TS cells showing local reversals of imprinted X-chromosome inactivation (K4GFP). Data also includes H3K27me3 ChIP-chip profiles in Eed-/- mutant male and female TS cells ...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-32655 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of E15.5 mouse Insm1, Neurod1 and Pax6 knockouts vs Insm1GFP.Cre/+ controls
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1GFP.Cre/+ controls and Insm1 (Insm1GFP.Cre/GFP.Cre), Neurod1 (Insm1GFP.Cre/+; Neurod1LacZ/LacZ), or Pax6 (Insm1GFP.Cre/+; Pax6fl/fl) knockout FACS sorted pancreatic endocrine cells at E15.5. Comparison of Insm1GFP.Cre+/...
ORGANISM(S): Mus musculus 
2021-08-23 | E-MTAB-10262 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of endocrine cell differentiation by Insm1
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1^GFP/Pdx1^CFP HIGH [het/het] FACS sorted pancreatic cells (pre-beta cells) and Insm1^GFP/Pdx1^CFP LOW [het/het] cells (other endocrine progenitors) at E15.5 and E18.5. Comparison of Insm1 +/Pdx HIGH and Insm1 +/Pdx LO...
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-1929 | biostudies-arrayexpress
UnknownDecoding allosteric regulation by the acyl carrier protein.
Not available
S-EPMC8072227 | biostudies-literature
GenomicsPtf1a and RbpjL ChIP-seq in mouse pancreas
Ptf1a and RbpjL form a complex. We wanted to identify genes that are regulated by the complex and distinguish those possibly regulated independently by Ptf1a and RbpjL in mouse pancreas using ChIP-seq technology. Chromatin Immunoprecipitations (ChIPs) for Ptf1a and RbpjL were performed with a number...
ORGANISM(S): Mus musculus 
2014-12-23 | E-MTAB-3197 | biostudies-arrayexpress
UnknownRictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
Not available
S-EPMC2896829 | biostudies-literature
UnknownFUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors.
Not available
S-EPMC5750046 | biostudies-literature
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