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TranscriptomicsChromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients
Comment on published article "Massive genomic rearrangement acquired in a single catastrophic event during cancer development." by Stephens, P.J., Greenman, C.D., Beiyuan, F., Yang, F., Bignell, G.R., Mudie, L.J., Pleasance, E.D., Lau, K.W., Beare, D., Stebbings, L.A., et al. (2011). Cell ...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-27560 | biostudies-arrayexpress
UnknownMolecular Signature of 18F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study.
Not available
S-EPMC9258580 | biostudies-literature
UnknownThe DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability.
Not available
S-EPMC8351364 | biostudies-literature
UnknownConstraints on signaling network logic reveal functional subgraphs on Multiple Myeloma OMIC data.
Not available
S-EPMC5872385 | biostudies-literature
TranscriptomicsA predictive and prognostic 38-gene expression signature for metastatic relapse in breast cancer
Background Currently, no gene-expression signature (GES) established from node-positive cohorts, able to predict breast cancer evolution after systemic adjuvant chemotherapy, exists. Methods Gene-expression profiles of 252 node-positive patients (median follow-up: 7.7 years), mostly included in a ra...
ORGANISM(S): Homo sapiens 
2008-11-27 | E-GEOD-11264 | biostudies-arrayexpress
TranscriptomicsBortezomib inhibits mTOR pathway in multiple myeloma cells via induced expression of REDD1.
The combination of bortezomib and dexamethasone should become the reference induction treatment for multiple myeloma patients younger than 65 years. Pharmacogenomic profiles of genes involved in response to treatment may help to understand resistance. We performed gene expression profiling in 9 myel...
ORGANISM(S): Homo sapiens 
2010-02-14 | E-GEOD-11866 | biostudies-arrayexpress
UnknownThe shaping and functional consequences of the dosage effect landscape in multiple myeloma.
Not available
S-EPMC3907079 | biostudies-literature
TranscriptomicsGene expression profile alone is inadequate in predicting complete response in multiple myeloma
We have analyzed gene expression microarray datasets from four different clinical trials to assess accuracy of gene expression based signature in predicting treatment complete response in patients with multiple myeloma. Two of four datasets were made available via The Intergroupe Francophone du Myél...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-55145 | biostudies-arrayexpress
TranscriptomicsGenetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients.
Purpose Despite advances and significant improvement in survival, multiple myeloma (MM) remains incurable and nearly all patients relapse after treatment. Previous studies have shown a complex spectrum of diverse genetic alterations in almost all patients, but evolution of genomic rearrangements th...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-25262 | biostudies-arrayexpress
TranscriptomicsExpression of genetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients
Series GSE25262 patients on expression side. [Exon study] 11 myeloma patients at diagnosis and relapse examined with Exon expression chip
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-37414 | biostudies-arrayexpress
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