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ProteomicsIon mobility tandem mass spectrometry enhances performance of bottom-up proteomics
We describe a novel method utilizing ion mobility-based concentration of peptide fragment ions on a qTOF mass spectrometer improving the sensitivity of bottom-up proteomics by up to 10-fold. This enabled the identification of 7,500 human proteins within one day and 8,600 phosphorylation sites within...
ORGANISM(S): Homo sapiens (Human) 
2015-08-18 | PXD000863 | Pride
Quadrupole time of flight mass spectrometer Proteomics Ion mobility mass spectrometry Chemical proteomics Phosphoproteomics 
TranscriptomicsMicroarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Bone is the most frequent site of metastasis in prostate cancer (PCa) and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow (BM) prior to surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This promp...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-59631 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression and identification of RNA polymerase, RpoD, and RpoS binding sites in Klebsiella pneumoniae MGH 78578
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae MGH 78578 
2012-12-31 | E-GEOD-36055 | biostudies-arrayexpress
TranscriptomicsTranslational control in early adipogenesis
In obesity, adipose tissue expands by increasing the volume of existing adipocytes (hypertrophy), increasing the number of small adipocytes (hyperplasia) or both. Much is known about transcriptional control during adipogenesis, including early events. However, translational control plays a pivotal r...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-29744 | biostudies-arrayexpress
ProteomicsInflammation primes the kidney for recovery by activating AZIN1 A-to-I editing
The progression of kidney disease varies among individuals, but a general methodology to quantify disease timelines is lacking. Particularly challenging is the task of determining the potential for recovery from acute kidney injury following various insults. Here, we report that quantitation of post...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-18 | MSV000093887 | MassIVE
TranscriptomicsAgo-RIP-Seq Analysis to Identify miR-375 Targets in Human Macrophages
miR-375 is not expression in human macrophages, however there is an enhanced accumulation of miR-375 in macrophages upon coculture with breast cancer cells. The target landscape of this miR in macrophages is not known. Ago-RIP-Seq was aimed to identify miR-375 targets in human macrophages.
ORGANISM(S): Homo sapiens 
2019-02-08 | E-MTAB-6943 | biostudies-arrayexpress
TranscriptomicsReliable single cell array CGH for clinical samples
Establishment and subsequent validation of a aCGH protocol for WGA (whole genome amplification) products originating from single cell or low amount of starting material (i.e. microdissected FFPE tissue samples). The establishment of the protocol involved testing of three DNA labeling protocols. Two ...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52366 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of RNA polymerase, RpoD, and RpoS binding sites in Klebsiella pneumoniae MGH 78578
Genome-wide identification of RNA polymerase (RNAP) binding sites were performed in Klebsiella pneumoniae MGH 78578 (KP). Anti-RNAP is used to capture the RNAP in KP. ChIP-chip was performed on tiling array specifically made for KP. Comparison ChIP by anti-RNAP antibody vs ChIP by normal mouse IgG (...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae MGH 78578 
2012-12-31 | E-GEOD-35927 | biostudies-arrayexpress
UnknownGenomic investigations of unexplained acute hepatitis in children.
Not available
S-EPMC10170458 | biostudies-literature
UnknownEvaluation of Autoantibody Binding to Cardiac Tissue in Multisystem Inflammatory Syndrome in Children and COVID-19 Vaccination-Induced Myocarditis.
Not available
S-EPMC10196878 | biostudies-literature
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