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UnknownRobust CRISPR-Cas9 Genetic Editing of Primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Cells.
Not available
S-EPMC10249715 | biostudies-literature
UnknownAbrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22).
Not available
S-EPMC3347656 | biostudies-literature
UnknownPre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia.
Not available
S-EPMC7192845 | biostudies-literature
UnknownThe SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma.
Not available
S-EPMC12311176 | biostudies-literature
ProteomicsHMG20B stabilizes interaction of LSD1 with GFI1 on chromatin to confer 1 transcription repression and leukemia cell differentiation block
Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukaemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has a critical scaffolding function at genomic sites occupied by the SNAG domai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD030581 | Pride
Human ltq orbitrap velos 
ProteomicsSOX11-SMARCA4 Complex Drives Oncogenic Gene Regulation in Mantle Cell Lymphoma
SOX11 pioneer transcription factor is aberrantly expressed, it has an oncogenic role and its overexpression associates with worse prognosis in patients with mantle cell lymphomas (MCL). Using a proximity labeling (BioID2)/Mass Spectrometry-based proteomic strategyies, we identified SMARCA4, the cent...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD051143 | Pride
Smarca4 Cut&run-sequencing. Sry-related hmg-box 11 (sox11) Mantle cell lymphoma Swi/snf chromatin remodeling complex Pioneer transcription factor 
UnknownHMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block.
Not available
S-EPMC7613766 | biostudies-literature
ProteomicsRetroviral transduction of NOTCH1 into primary human Chronic Lymphocytic Leukemia cells unravels immune escape-mechanisms
Functional studies to investigate gene mutations recurrent in B cell lymphoma have been hampered by the inability to genetically manipulate primary cells, attributed to low transduction efficacy and procedure-associated toxicity. Alternative approaches utilize cell lines and mouse models, which ofte...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD024112 | Pride
Notch1 Mutated gene Chronic lymphocytic leukemia (cll) Co-activator ciita Mantle cell lymphoma (mcl) Hla-class ii locus 
UnknownThe molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia.
Not available
S-EPMC5596207 | biostudies-literature
ProteomicsNUP98-HOXA9 acute myeloid leukemia
Mass Spectrometry analysis of the interactome of the oncoprotein NUP98-HOXA9
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD001828 | Pride
Fusion protein nup98-hoxa9 Protein-protein interactions Aml 
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