Dataset Information

SOX11-SMARCA4 Complex Drives Oncogenic Gene Regulation in Mantle Cell Lymphoma

ABSTRACT: SOX11 pioneer transcription factor is aberrantly expressed, it has an oncogenic role and its overexpression associates with worse prognosis in patients with mantle cell lymphomas (MCL). Using a proximity labeling (BioID2)/Mass Spectrometry-based proteomic strategyies, we identified SMARCA4, the central catalytic subunit of the SWI/SNF chromatin-remodeling complex, as one of the most significant SOX11-specific interacting proteins. SMARCA4 expression is directly regulated by SOX11, and its upregulation is associated with worse overall survival in patients with MCL, independently of other high-risk factors. Integration of global DNA-binding and transcriptomic profiles revealed that SOX11 and SMARCA4 share 60% specific peaks, predominantly in promoter regions. Disruption of SOX11:SMARCA4 interaction via SOX11 knockout or SMARCA4 PROTAC-degradation significantly reduced co-occupancy and co-targeted gene expression, including key BCR signaling pathway components. Our results suggest that SOX11:SMARCA4 complex binds to common regulatory sequences enabling the accession to chromatin and transcriptomic regulation of key oncogenic pathways for the development of MCL pathogenesis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell

DISEASE(S): Mantle Cell Lymphoma

SUBMITTER: Paula Carrillo Rodríguez

LAB HEAD: Virginia Amador

PROVIDER: PXD051143 | Pride | 2025-08-04

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	210819_VirginiaAmador_2021-025.pdStudy	Other
	4031_FC_V_Ctrl_01_EE.msf	Msf
	4031_FC_V_Ctrl_01_EE.raw	Raw
	4031_FC_V_Ctrl_02_EE.msf	Msf
	4031_FC_V_Ctrl_02_EE.raw	Raw

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Publications

The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma.

De Bolòs Anna A Carreras-Caballé Maria M Sureda-Gómez Marta M Rodríguez Marta-Leonor ML Charalampopoulou Stella S Albero Robert R Maiques-Diaz Alba A Playa-Albinyana Heribert H Clot Guillem G López Cristina C Colomer Dolors D Martin-Subero José I JI Campo Elías E Reverter David D Villanueva Josep J Amador Virginia V

Blood cancer journal 20250730 1

Mantle cell lymphoma (MCL) is considered one of the most aggressive B-cell lymphoid neoplasms. The transcription factor SOX11 is aberrantly expressed in conventional aggressive MCL, while it is not or weakly expressed in the leukemic non-nodal MCL subtype with a predominantly indolent clinical evolution. SOX11 is a key driver of MCL through the regulation of several oncogenic mechanisms, suggesting that it may be interacting with different protein complexes to exert its multiple actions. Using p ...[more]

PMID: 40739087

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