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TranscriptomicsMajor Depressive Disorder blood gene expression
Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. Methods: We used a classifier approach on blood gene expression profiles of a unique set of non-medicated su...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
MetabolomicsEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse mod...

2021-01-21 | MTBLS121 | MetaboLights
ProteomicsiTRAQ paroxetine response in major depressive disorder
Identify blood proteins relevant to paroxetine response in patients with major depressive disorder (MDD)
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD028947 | Pride
Human  pbmc  itraq  mdd  paroxetine 
MetabolomicsEffects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in fla...
2020-06-03 | MTBLS952 | MetaboLights
GenomicsHypermethylation in the ZBTB20 gene is associated with major depressive disorder
Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an indepe...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-54222 | biostudies-arrayexpress
GenomicsHypermethylation in the ZBTB20 gene is associated with major depressive disorder
Genome-wide MeDIP-Sequencing of 23 monozygotic twin pairs (n=46) from Australia discordant for major depressive disorder (MDD). MeDIP-seq of 23 monozygotic twin pairs discordant for major depressive disorder. MZ twin pairs were compared to identify significantly differently methylated sites associat...
ORGANISM(S): Homo sapiens 
2014-01-25 | E-GEOD-54370 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (26 samples BA25_F)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54571 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (24 samples BA25_M)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54572 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain amygdala - including control samples and samples with major depression disorders (42 samples MD3_AMY)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54564 | biostudies-arrayexpress
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