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ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080865 | MassIVE
UnknownEvaluating biological activity of compounds by transcription factor activity profiling.
Not available
S-EPMC6157966 | biostudies-literature
UnknownMilestoning estimators of dissipation in systems observed at a coarse resolution.
Not available
S-EPMC11047069 | biostudies-literature
MetabolomicsCryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
ProteomicsH.sapiens - Cell line, SC (Scheltemaetal,molcellproteomics,2014)
abundance based on Spectral counting, Interaction consistency score: 19.1, Coverage: 27
ORGANISM(S): 9606 
2014-00-00 | 4132152676 | PAXDB
UnknownPotential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals.
Not available
S-EPMC6467772 | biostudies-literature
UnknownAggregation, Cytotoxicity and DNA Binding in a Series of Calix[4]arene Amphiphile Containing Aminotriazole Groups.
Not available
S-EPMC10224245 | biostudies-literature
ProteomicsExperimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
In this study, we developed a model system for the assessment of small molecule-protein interactions using intact cells treated with a commercially available highly specific mitogen-activated protein kinase (MEK) 1/2 inhibitor to prepare a set of unfractionated test samples labeled with tandem mass ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034087 | Pride
Cetsa Mass spectrometry Tpp Target identification Thermal stability assays Drug-protein interactions 
ProteomicsExperimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
Mass spectrometry (MS)-based thermal stability assays have recently emerged as one of the most promising solutions for the identification of protein-ligand interactions. Here, we have investigated eight combinations of several recently introduced MS-based advancements, including the Phase-Constraine...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040284 | Pride
Cetsa Mass spectrometry Tpp Target identification Thermal stability assays Drug-protein interactions 
UnknownCalix[4]arene Polyamine Triazoles: Synthesis, Aggregation and DNA Binding.
Not available
S-EPMC9738031 | biostudies-literature
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