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MetabolomicsTowards improving point-of-care diagnosis of non-malaria febrile illness: a metabolomics approach
Background: Non-malaria febrile illnesses such as bacterial bloodstream infections (BSI) are a leading cause of disease and mortality in the tropics. However, there are no reliable, simple diagnostic tests for identifying BSI or other severe non-malaria febrile illnesses. We hypothesized that differ...
2016-03-17 | MTBLS315 | MetaboLights
MetabolomicsMetabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action
Not available
ORGANISM(S): Plasmodium falciparum 
ST000414 | MetabolomicsWorkbench
MetabolomicsMaternal lipid mobilization is essential for embryonic development in a key malaria vector
Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...
2024-11-05 | MTBLS9881 | MetaboLights
TranscriptomicsExpression data from whole blood samples of Rwandan adults with mild malaria with matched sample thirty days later (convalescence)
Host factors governing mild disease in adults who have developed clinical immunity to Plasmodium falciparum may provide insights for disease altering vaccine or interventions, to prevent severe malaria We used microarrays of whole blood samples during mild malaria and compared them in a paired analy...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-64338 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria
Using genome-wide expression profiles from persons either experimentally challenged with malaria-infected mosquitoes or naturally-infected with Plasmodium falciparum malaria, we present details of the transcriptional changes that occur with infection and that are either commonly shared between subje...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5418 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of peripheral blood from Gambian children with severe or uncomplicated Plasmodium falciparum malaria
This study examined the differences in human and parasite gene expression pattern between children with severe malaria and those with uncomplicated malaria through a dual RNA-seq approach. Peripheral blood samples were collected which contained substantial numbers of parasites that required no RNA e...
ORGANISM(S): Homo sapiens 
2018-06-20 | E-MTAB-6413 | biostudies-arrayexpress
GenomicsInsights into the epigenomic landscape of the human malaria vector Anopheles gambiae
We characterize the epigenome of the human malaria vector Anopheles gambiae in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq. Ch...
ORGANISM(S): Anopheles gambiae 
2014-09-04 | E-GEOD-59773 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Plasmodium vivax derived from clinical isolates
This project contains RNA-sequencing reads of Plasmodium vivax derived directly from clinical patients. Here, we aim to characterize the gene expression patterns in patients with various parasite compositions. Patients (n=10) were recruited from two malaria endemic areas in Thailand. Ten RNA samples...
ORGANISM(S): Homo sapiens 
2019-06-30 | E-MTAB-6753 | biostudies-arrayexpress
MetabolomicsMaHPIC Experiment HuC - Metabolomics of plasma samples from human volunteers infected with Plasmodium vivax
Project Description:
The Malaria Host-Pathogen Interaction Center (MaHPIC) is a transdisciplinary malaria systems biology research program initially supported by an NIH/NIAID contract (HHSN272201200031C, 2012-2017; see http://w...
2018-06-19 | MTBLS665 | MetaboLights
TranscriptomicsExpression profiling of hemocytes from Anopheles gambiae after malaria parasite infection
Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation, and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides. In Anopheles, they contribute to the defense against malaria parasite invasion during the early s...
ORGANISM(S): Anopheles gambiae 
2009-10-29 | E-GEOD-17866 | biostudies-arrayexpress
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