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MetabolomicsSingle-cell lipidomic analysis of the Epithelial-Mesenchymal Transition (EMT) using MALDI-MSI

EMT is a metastasis-promoting process whose heterogeneity has been extensively studied at a gene expression level. EMT also involves reprogramming of lipid metabolism, however there has been little focus on heterogeneity on the lipid level. Here, we use MALDI-MSI to determine the levels of variou...

2026-04-15 | MTBLS12650 | MetaboLights
MetabolomicsAssessing the potentiality of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications (Liver MALDI-MSI assay)

Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), but some organic matrices used in classical MALDI ...

2022-01-21 | MTBLS589 | MetaboLights
MetabolomicsAssessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications (Brain MALDI-MSI assay)

Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), mainly due to the large variety of analyte classes...

2022-01-21 | MTBLS588 | MetaboLights
MetabolomicsSeagrasses excrete sugars to their rhizosphere making them the sweet spots in the sea (Plant roots; MALDI-MSI assay)

Seagrasses are one of the most efficient natural sinks of carbon dioxide (CO2) on Earth. Despite covering less than 0.1% of coastal regions, they have the capacity to bury up to 10% of marine organic matter and can bury the same amount of carbon 35 times faster than tropical rainforests. On land,...

2022-01-28 | MTBLS1746 | MetaboLights
ProteomicsBottom-up spatial proteomics MALDI MSI
New workflow for spatial bottom-up proteomics at single-cell resolution.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056528 | Pride
Maldi msi Spatial proteomics 
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Mus Musculus (ncbitaxon:10090) 
MSV000086102 | MassIVE
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2020-08-06 | PXD011104 | Pride
Protease activity Maldi-msi 
ProteomicsRegion-specific lipid markers of plaque outcome revealed by mass spectrometry imaging of human carotid atherosclerotic plaques
The goal of the project is the detection of region-specific lipid features that discriminate between symptomatic and asymptomatic human carotid atherosclerotic plaques by MALDI MSI.
ORGANISM(S): Homo sapiens (Human) 
2025-01-04 | PXD039822 | Pride
Atherosclerosis Maldi msi Lipids Plaque outcome 
ProteomicsMass spectrometry imaging of ancient teeth proteomes
In order to research the variation in protein distribution in teeth, proteins were extracted from archaeological (15-18th century, Netherlands) and modern teeth and identified using LC-MS/MS. Of the recovered proteins we then visualised the distribution of collagen type I (both the alpha-1 and -2 ch...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038114 | Pride
Palaeoproteomics Teeth Protein distribution Maldi-msi Diagenesis 
ProteomicsCancer tissue classification using machine learning applied to MALDI MSI and high resolution H&E stained images
Aim is to identify a panel of m/z markers for the early detection of colorectal cancer (CRC). Identification of a molecular pattern that can distinguish the primary tumours of colorectal cancer with lymph node metastasis compared to those without. Materials and Methods: Using MALDI MSI data, we deve...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019662 | Pride
Crc colorectal cancer machine learning maldi msi matrix assisted laser desorption/ionisation mass spectrometry imaging 
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