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TranscriptomicsRNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-sequencing was performed to investigate the role of the Candida albicans protein kinase Sky2 in metabolic adaptation to alternative carbon sources. The Candida albicans wildtype strain SC5314 and a sky2 deletion mutant were grown in medium with either glucose (3h), malic acid (6h) or succinic ac...
ORGANISM(S): Candida albicans 
2026-04-01 | E-MTAB-16222 | biostudies-arrayexpress
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Untargeted assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prosta...

2023-04-17 | MTBLS6039 | MetaboLights
GenomicsMetabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH
Metabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH
PRJNA836886 | ENA
TranscriptomicsMetabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH
Soluble pyridine nucleotide transhydrogenase (EcSthA) derived from Escherichia coli was introduced into the L-malic acid producing strain MA009-5 of Pichia kudriavzevii to obtain strain MA009-10. It was found that MA009-10 was superior to MA009-5 in terms of L-malic acid titer, glucose consumption r...
ORGANISM(S): Pichia kudriavzevii 
2023-05-03 | GSE202655 | GEO
ProteomicsProteomics of B16-F10 cells treated by carboxylic acids
To elucidate the mechanisms by which the four carboxylic acids—3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and malic acid—inhibit melanin production in B16-F10 cells, a comparative proteomic analysis was conducted to assess changes in protein expression.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD061919 | Pride
L-pyroglutamic acid 3-phenyllactic acid Lactic acid Malic acid 
GenomicsLignin degradation as a crucial factor in consolidated bioprocessing for malic acid production by Myceliophthora thermophila
Lignin degradation as a crucial factor in consolidated bioprocessing for malic acid production by Myceliophthora thermophila
PRJNA1182718 | ENA
TranscriptomicsLignin degradation as a crucial factor in consolidated bioprocessing for malic acid production by Myceliophthora thermophila
Consolidated bioprocessing (CBP) represents a promising approach to convert biomass into valuable chemicals by integrating the hydrolysis of cellulose and hemicellulose with microbial fermentation in a single step. This study investigates the potential of CBP technique for the efficient conversion o...
ORGANISM(S): Thermothelomyces thermophilus 
2026-08-19 | GSE281203 | GEO
GenomicsRNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
PRJEB104101 | ENA
Genomics
L-Malic acid treated macrophage sequencing
PRJNA957562 | ENA
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