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ProteomicsSecond messenger control of mRNA translation by dynamic ribosome modification
Pseudomonas species employ complex, dynamic signalling networks to fine-tune responses to changing environments, with regulation taking place at the transcriptional, post-transcriptional and post-translational levels. Control of mRNA translation and hence protein abundance is a crucial element of th...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2020-06-30 | PXD017233 | Pride
Signalling Pseudomonas Ribosomal proteins Cyclic-di-gmp Itraq proteome 
ProteomicsAn integrative, multi-omics analysis of the Hfq regulon
The ability of bacteria to respond to environmental change is based on the exploration of sophisticated regulatory landscapes. While we can learn a great deal from reductive analyses of individual pathways, and global approaches to gene regulation, a deeper understanding of these complex signalling ...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2017-10-18 | PXD005621 | Pride
Hfq Pseudomonas fluorescens Posttranscriptional regulation Multi-omics Proteomics Isobaric labelling 
ProteomicsGlobal control of bacterial translation by a specific ribosomal modification
Translational regulation plays a critical role in controlling the environmental responses of diverse bacterial species. In addition to existing, well-established regulatory pathways, the alteration of ribosome function by specific posttranslational modification represents a potential further mechani...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD001371 | Pride
Pseudomonas Translational regulation Ribosome Rhizosphere 
ProteomicsGlobal control of bacterial translation by a specific ribosomal modification
Translational regulation plays a critical role in controlling the environmental responses of diverse bacterial species. In addition to existing, well-established regulatory pathways, the alteration of ribosome function by specific posttranslational modification represents a potential further mechani...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD001376 | Pride
Pseudomonas Translational regulation Ribosome Rhizosphere 
ProteomicsTranslational regulation via ribosome modification
This dataset compares the proteomes of WT P. fluorescens and a delta-hfq mutant strain. This forms part of our characterisation of a new mechanism for translational control in bacteria, based on the covalent modification of a ribosomal protein by the enzyme RimK. RimK modification induces specific e...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD002573 | Pride
Pseudomonas Translational control Ribosomal modification Lc-ms/ms 
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Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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