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MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
MetabolomicsOptimization of redox metabolite detection in mammalian cells (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001765 | MetabolomicsWorkbench
MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14245 | MetaboLights
MetabolomicsOptimization of redox metabolite detection in mammalian cells (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001772 | MetabolomicsWorkbench
MetabolomicsAnti-oxidative metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (IV)
Not available
ORGANISM(S): Homo sapiens 
ST001977 | MetabolomicsWorkbench
MetabolomicsAnti-oxidation metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (III)
Not available
ORGANISM(S): Mus musculus 
ST001976 | MetabolomicsWorkbench
MetabolomicsAnti-oxidative metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (II)
Not available
ORGANISM(S): Mus musculus 
ST001975 | MetabolomicsWorkbench
MetabolomicsAnti-oxidation metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (VI)
Not available
ORGANISM(S): Mus musculus 
ST001979 | MetabolomicsWorkbench
MetabolomicsAnti-oxidative metabolism measurement in mammalian cells and tissues by quantitative LC/MS method (I)
Not available
ORGANISM(S): Mus musculus 
ST001974 | MetabolomicsWorkbench
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