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TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52623 | biostudies-arrayexpress
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52595 | biostudies-arrayexpress
TranscriptomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [expression]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46645 | biostudies-arrayexpress
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [ChIP-seq]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46587 | biostudies-arrayexpress
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [Mnase-Seq II]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46586 | biostudies-arrayexpress
ProteomicsRole of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance seen in 10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine pros...
ORGANISM(S): Homo sapiens (Human) 
2020-11-04 | PXD016861 | Pride
Swi/snf complex Lineage plasticity Prostate cancer Epigenetic 
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [Mnase-Seq I]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-38670 | biostudies-arrayexpress
ProteomicsExploring the interaction between the SWI/SNF chromatin remodeling complex and the zinc finger factor CTCF
The transcription factor CCCTC-binding factor (CTCF) modulates pleiotropic functions mostly related to gene expression regulation. The role of CTCF in large scale genome organization is also well established. A unifying model to explain relationships between many CTCF-mediated activities involve dir...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022037 | Pride
Ctcf  swi/snf  brg1  mass spectrometry  protein‐protein interaction  brk  transcription factor  chromatin 
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52231 | biostudies-arrayexpress
GenomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [ChIP-Seq]
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52277 | biostudies-arrayexpress
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