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TranscriptomicsGene expression of RonTK-/- mammary glands compared to RonTK+/+ controls during development
RON WT and RON KO at 5, 6, 7 week virgin mammary glands In the study, we demonstrated that RON regulates mammary gland branching morphogenesis in pubertal development associated with changes in gene expression. Keywords: Pubertal mammary glands In the study, we hybridized RNA from 5, 6, 7 week old ...
ORGANISM(S): Mus musculus 
2009-06-16 | E-GEOD-16629 | biostudies-arrayexpress
TranscriptomicsInfluence of intrauterine low protein diet on ductal morphogenesis of the rat mammary gland.
Following intrauterine low protein diet, the lumbar mammary gland of control and low protein rats were removed for further analysis via genarray on day 21 and day 28 postpartum. Virgin female Wistar rats came from Charles River. Throughout pregnancy the NP rats received 25g/d of Altromin C1000 conta...
ORGANISM(S): Rattus norvegicus 
2014-06-24 | E-GEOD-34136 | biostudies-arrayexpress
ProteomicsMouse Mammary Gland Morphogenic Differences with BAD 3SA Mutant
The identification of genes driving organ development is central to understanding which signaling pathways drive the pathogenesis of various diseases including cancer. This dataset depicts the proteomic changes observed in C57BL/6J mice expressing wild-type or 3SA-phospho mutant versions of the Bcl-...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-29 | PXD014347 | Pride
Breast Mammary morphogenesis Mouse Breast cancer Mammary gland Bad Lc-ms/ms 
TranscriptomicsAnalysis of Gene Expression in PTHrP-/- Mammary Buds
Analysis of Gene Expression in PTHrP-/- Mammary Buds Supports a Role for BMP Signaling and MMP2 in the Initiation of Ductal Morphogenesis. Parathyroid hormone-related protein (PTHrP) acts on the mammary mesenchyme and is required for proper embryonic mammary development. In order to understand PTHrP...
ORGANISM(S): Mus musculus 
2009-08-15 | E-GEOD-17654 | biostudies-arrayexpress
TranscriptomicsPrimary Mammary Epithelial Cells: Control vs 1023-Treated
Gene expression profiling of primary mammary epithelial cells treated for 72 hours with compound 1023 compared to DMSO. Goal was to determine genes differntially regulated by treatment with the novel compound, 1023. Two-condition experiment, DMSO vs. 1023. Biological replicates: 2 control replicate...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39249 | biostudies-arrayexpress
TranscriptomicsQuantification of regenerative potential in primary human mammary epithelial cells
We present an organoid regeneration assay in which freshly dissociated human mammary epithelial cells from healthy donors are grown in adherent/rigid or floating/compliant collagen I gels. In both conditions, luminal progenitors (CD49f+EpCAM+) form spheres, whereas basal cells (CD49fhiEpCAM-) genera...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-64248 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis of Embryonic Mammary Cells
The mammary primordium represents the earliest evidence of commitment to the mammary lineage. The primordium forms via inductive tissue interactions between its constitutive tissues, the mesenchyme and epithelium. Here, we describe an analysis of the transcriptome of the mammary bud epithelium and i...
ORGANISM(S): Mus musculus 
2011-11-11 | E-TABM-1099 | biostudies-arrayexpress
TranscriptomicsTime course gene expression profiling of mouse mammary gland TEB and duct cells throughout branching morphogenesis
Branching morphogenesis of the mammary gland is driven by the highly motile terminal end bud (TEB) throughout pubertal development. The stem cell enriched, proliferative TEB branches as it invades the mammary fat pad to create a complex network of ducts. The gene expression programs specific to the ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-57724 | biostudies-arrayexpress
TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
TranscriptomicsCrkII transgene induces atypical mammary gland development and tumorigenesis
The v-Crk protein was originally isolated as the oncogene fusion product of the CT10 chicken retrovirus. Cellular homologues of v-Crk include Crk, which encodes two alternatively spliced proteins (CrkI and CrkII), and CrkL. Though CrkI/II proteins are elevated in several types of cancer, including b...
ORGANISM(S): Homo sapiens 
2011-07-17 | E-GEOD-30731 | biostudies-arrayexpress
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